| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 14
| Issue : 2 | Page : 100-106 |
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Estimation of Matrix Metalloproteinases-9 (MMP-9) Levels in Children with Early Childhood Caries
Ngangbam Reenayai, Manju Raman Nair
Department of Pediatric and Preventive dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru, India
Correspondence Address:
Dr. Manju Raman Nair
Professor and Head of the Department, Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka 575018
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jofs.jofs_65_22
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Introduction: The primal incidence of dental caries is from the childhood. To assess the levels of salivary MMP-9 in children with Early Childhood Caries following caries control. Materials and Methods: 45 children between the age group of 3-5 years were selected for the study and divided into three groups of 15 each. Group A was the control group. The salivary samples were collected before any treatments in ECC (Group B) and S-ECC (Group C), following which caries control measures were done. Following 2 weeks of post-treatment, the saliva samples were collected from experimental Groups and tested for salivary MMP-9, pH, and viscosity levels. Results: The mean value of the salivary MMP-9, pH, and viscosity levels estimated in the control group of children was 7.13 ng/ml (±0.809 mg/ml), 7.06 (±0.338), and 0.41 (±0.072) respectively. The pre-treatment salivary MMPs, pH, and viscosity levels estimated in Group B were 10.95 ng/ml (±1.469 ng/ml), 7.07 (±0.403), and 1.74 (±0.412) respectively, and in Group C these values were 18.55 ng/ml (±9.218ng/ml), 6.92 (±0.542) and 1.28 (±0.123) respectively. The post-treatment salivary MMP-9, pH and viscosity levels estimated in Group B were 7.34 ng/ml (±0.673 ng/ml), 7.24 (±0.394), and 0.42 (±0.208) respectively and in Group C these values were 7.84 ng/ml (±0.647 ng/ml), 7.14 (±0.377) and 0.49 (±0.338), respectively after 2 weeks. Conclusion: The salivary MMP-9 and viscosity levels in groups B and C decreased significantly 2 weeks following caries control. The Salivary MMP-9 level is a good diagnostic and prognostic biomarker for comparing the efficacy of various caries control treatment protocols. comparing the efficacy of various caries control treatment protocols.
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