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Year : 2012  |  Volume : 4  |  Issue : 2  |  Page : 133-136

Nasolabial cyst: Report of a case

1 Department of Oral and Maxillofacial Pathology, Best Dental Science College, Madurai, Tamil Nadu, India
2 Medical Practitioner, Tamil Nadu, India
3 Dental Surgeon, Rotorua, NewZealand

Date of Web Publication17-Jan-2013

Correspondence Address:
A. Sri Kennath J Arul
No.7A, VOC Street, Alagappan Nagar, Madurai, Tamil Nadu - 625 003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-8844.106212

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The nasolabial cyst is an uncommon non-odontogenic cyst arising in the maxillofacial tissues. This lesion presents in an extraosseous location in the region of the nasolabial fold and can cause swelling in the furrow, alar nose elevation, and upper lip projection. Despite the uncommon occurrence of nasolabial cysts, it is important to recognize the characteristics of this lesion. The paper documents the presentation of nasolabial cyst in a 33 year old woman and discusses considerations related to the diagnosis.

Keywords: Cyst, diagnosis, nasolabial, non-odontogenic

How to cite this article:
Arul AJ, Verma S, Arul AJ, Verma R. Nasolabial cyst: Report of a case. J Orofac Sci 2012;4:133-6

How to cite this URL:
Arul AJ, Verma S, Arul AJ, Verma R. Nasolabial cyst: Report of a case. J Orofac Sci [serial online] 2012 [cited 2021 May 6];4:133-6. Available from:

  Introduction Top

The nasolabial cyst (NC) is a rare non-odontogenic cyst originating in the maxillofacial soft tissues. [1] It represents about 0.7% of all cysts in the maxillofacial region, [2] 2.5% of the non-odontogenic cysts. [1] Many authors believe that its prevalence is actually higher than that presented in the literature; however, due to misdiagnosis, indexes remain low. [1]

These cysts, unless infected, cause painless swelling around the nasal vestibule and upper lip, and infrequently lead to nasal stuffiness. [3],[4] Typically, they appear as a swelling at canine fossa, upper lip, gingivo-labial sulcus, nasal alae and nasal vestibule. [3] Despite the fact that they are soft tissue cysts and are situated extra-osseously, they may sometimes cause bone destruction. [5] The initial diagnosis and treatment is usually made in early stages because the lesion causes cosmetic problems; very rarely it becomes large in dimensions.

Commonly seen in adults, it has peak prevalence in the 4 th -5 th decade of life. [6] A greater incidence is seen in females (4:1). It is usually unilateral in occurrence with no predilection in side. [2] However, 11.2% cases have been reported to be bilateral. [7]

This paper documents the presentation of nasolabial cyst in a 33 year old woman and discusses considerations related to the diagnosis.

  Case Report Top

A 33 year old woman was referred to our service for the evaluation of a painless swelling lateral to right ala of the nose that had appeared one month earlier with gradual evolution. Medical history was non-contributory to the present complaint. Extra-oral examination revealed a diffuse swelling lateral to right ala of the nose resulting in elevation of alae and obliteration of the nasolabial fold [Figure 1]a. On palpation, the swelling was soft in consistency, fluctuant and non-tender. On intra-oral examination, swelling distending the right maxillary labial sulcus [Figure 1]b was evident that was soft, fluctuant and non-tender on palpation.
Figure 1:

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A history of extraction with respect to permanent maxillary right first molar and maxillary left first premolar done two years back was the only past dental intervention. The teeth in the vicinity of the swelling showed proximal caries but were tested vital.

Intra-oral periapical and panoramic radiographs revealed no obvious bony changes. Maxillary occlusal view revealed slight erosion of right side of the palate due to pressure exerted by the lesion [Figure 2]. Aspiration of the swelling yielded a straw-colored fluid [Figure 3]. Based on clinical and radiographic diagnosis, a working diagnosis of nasolabial cyst was made. The clinical differential diagnosis included epidermoid inclusion cyst, salivary gland cyst.
Figure 2: Maxillary occlusal radiograph revealed slight erosion of right side of the palate

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Figure 3: Aspiration yielded straw-colored fluid

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Under local anesthesia, using a vestibular incision, the cysts were enucleated and submitted for histopathological examination. Microscopic evaluation revealed a cystic lumen lined predominantly by pseudo-stratified columnar epithelium with varying number of goblet cells [Figure 4]a with part of lining composed of cuboidal epithelium [Figure 4]b. The fibrous cystic wall was relatively acellular, densely collegenous and exceedingly hemorrhagic. The features were consistent with the diagnosis of nasolabial cyst. Post-operative follow up at 8 months showed uneventful healing without evidence of recurrence.
Figure 4:

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  Discussion Top

The nasolabial cyst is a developmental, non-odontogenic cyst that most commonly involves the nasal furrow region. [8] According to Allard, the first description of this entity is recorded by Zukerkandl in 1882. [9] It has been given many names such as Klestadt's cyst, nasoalveolar cyst, nasal vestibular cyst, mucoid cyst of the nose, and nasal wing cyst. [10]

Regarding the pathogenesis, various theories of origin have been proposed. The first suggested that it is a retention cyst arising from inflamed mucus glands. [11],[12] Klestadt first postulated an embryologic origin for these cysts and considered that these lesions must originate from embryonic epithelium, entrapped in the developmental fissures between the lateral nasal and maxillary processes. [13] Since then, many authors have classified this entity based on Klestadt's embryologic theory as a fissural cyst. The third theory and the most accepted one raised by Bruggemann is that it arises from the remnants of the lower anterior part of the nasolacrimal duct. [14]

The clinical presentation is typical with an asymptomatic spherical swelling beneath the nasal ala causing its elevation and obliterating the nasolabial fold. Lesion distends the mucolabial sulcus intra-orally and can cause discomfort in denture users. [2] Most often patient may seek treatment because of the noticeable deformity, as was in the present case.

The diagnosis is essentially clinical. Bi-digital palpation reveals a fluctuating tumefaction between the floor of the nasal vestibule and the gingivolabial sulcus, which helps to confirm the diagnosis. Radiograms do not detect this soft tissue lesion except when it causes significant maxillary bone erosion. [15] Cohen and Hertzanu reported a case of NC with a high growth potential that resulted in the erosion of maxillary alveolus, invaded the supporting structures in the region of incisor teeth and caused their displacement. [16] In the present case, the occlusal radiograph revealed pressure erosion on right side of the palate, but there was no displacement of teeth. The teeth in the lesional area are vital unless affected by the pathosis unrelated to the cyst. [2] In the present case, there was no focus of dental infection in the lesional area and the teeth tested vital.

The differential diagnosis for a non-painful vestibular soft-tissue swelling within the anterior maxillary-alar region is not extensive, once conditions other than benign cysts are excluded. However, only nasolabial cyst presents exclusively in this area. Other soft-tissue lesions that can occur in this region include periapical inflammatory lesions (granuloma, cyst or abscess) that have perforated the bone. Vitality testing of the adjacent teeth can help to rule out this possibility. Very rarely, aggressive developmental odontogenic lesions, such as keratocyst, extend through the bone cortex to cause soft-tissue swelling. The long-standing nature of this lesion and the limited bone involvement made this diagnosis improbable. Developmental gingival cyst of the adult has a predilection for the bicuspid or canine region and might have been considered in this case. However, this lesion is usually localized in the gingival or contiguous alveolar mucosa and would not cause the distension of the vestibular mucosa that characterizes nasolabial cyst. Another possible cyst of non-odontogenic origin is the epidermoid or epidermal inclusion cyst. A distinguishing feature of this very rare cyst may be its yellow hue, as opposed to the normal pink or bluish coloration of a nasolabial cyst. Mucous extravasation cyst could also be considered. However, in such cases there is often a history of deflation and inflation as mucus within the lesion is periodically expressed and regenerated. As noted earlier, numerous non-odontogenic benign or malignant neoplasms may present in this area. Of particular significance are salivary gland neoplasms arising from minor salivary glands. [17]

Various treatment modalities have been considered for NC including injection of sclerosing agents, marsupalization and surgical enucleation. However, surgical enucleation through sublabial approach is the most accepted treatment modality. Recurrence have never been reported. [2] Malignant transformation is rare and has been documented in only one case. [18]

  Conclusion Top

Nasolabial cyst must be kept in mind in differential diagnosis of nasal vestibule, nasal base, and sublabial area. Although uncommon in occurrence, it is imperative for the clinician to make an accurate diagnosis and provide appropriate treatment. [2]

  References Top

1.Shear M, Speight PM. Cysts of the Oral and Maxillofacial Regions. 4 th ed. Singapore: Blackwell publishing limited; 2007. p. 119-22.  Back to cited text no. 1
2.Patil K, Mahima VG, Divya A. Klestadt's cyst: A rarity. Indian J Dent Res 2007;18:23-6.  Back to cited text no. 2
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3.el-Din K, el-Hamd AA. Nasolabial cyst: A report of eight cases and a review of the literature. J Laryngol Otol 1999;113:747-9.  Back to cited text no. 3
4.Fishman RA. Pathologic quiz case 2: Nasolabial (nasoalveolar) cyst. Arch Otolaryngol 1983;109:348-9,51.  Back to cited text no. 4
5.Barzilai M. Case report: Bilateral nasoalveolar cysts. Clin Radiol 1994;49:140-1.  Back to cited text no. 5
6.Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 2 nd ed. Philadelphia: WB Saunders; 2007. p. 25-6.  Back to cited text no. 6
7.Wesley RK, Scannell T, Nathan LE. Nasolabial cyst: Presentation of a case with a review of the literature. J Oral Maxillofac Surg 1984;42:188-92.  Back to cited text no. 7
8.Kamath VV, Satelur K, Yerlagudda K. Nasolabial cysts-report of four cases including two bilateral occurrences and review of literature. Indian J Dent 2011;2:156-9.  Back to cited text no. 8
9.Allard RH. Nasolabial cyst: Review of the literature and report of 7 cases. Int J Oral Surg 1982;11:351-9.  Back to cited text no. 9
10.Pereira Filho VA, Silva AC, Moraes Md, Moreira RW, Villalba H. Nasolabial cyst: Case report. Braz Dent J 2002;13:212-4.  Back to cited text no. 10
11.Kelly AB. Cysts of the floor of the nose. J Laryngol 1898;13:272-6.  Back to cited text no. 11
12.Kyrmizakis DE, Lachanas VA, Benakis AA, Velegrakis GA, Aslanides IM. Bilateral nasolabial cysts associated with recurrent dacryocystitis. J Laryngol Otol 2005;119:412-4.  Back to cited text no. 12
13.Klestadt WD. Nasal cysts and the facial cleft cyst theory. Ann Otol Rhinol Laryngol 1953;62:84-92.  Back to cited text no. 13
14.Brüggemann A. Zysten als Folge von Entwicklungsstorungen im Naseneingang. Arch Laryngol Rhinol 1920;33:101-5.  Back to cited text no. 14
15.Aquilino RN, Bazzo VJ, Faria RJ, Eid NL, Bóscolo FN. Nasolabial cyst: Presentation of a clinical case with CT and MR images. Braz J Otorhinolaryngol 2008;74:467-71.  Back to cited text no. 15
16.Cohen MA, Hertzanu Y. Huge growth potential of the nasolabial cyst. Oral Surg Oral Med Oral Pathol 1985;59:441-5.  Back to cited text no. 16
17.Nixdorf DR, Peters E, Lung KE. Clinical presentation and differential diagnosis of nasolabial cyst. J Can Dent Assoc 2003;69:146-9.  Back to cited text no. 17
18.López-Ríos F, Lassaletta-Atienza L, Domingo-Carrasco C, Martinez-Tello FJ. Nasolabial cyst: Report of a case with extensive apocrine change. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:404-6.  Back to cited text no. 18


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


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