ORIGINAL ARTICLE
Year : 2019  |  Volume : 11  |  Issue : 2  |  Page : 105-109

Caldesmon Expression in Metastatic and Non-Metastatic Oral Squamous Cell Carcinoma—A Mediator of Epithelial Mesenchymal Transition


1 Professor and Head of the Department, Department of Oral Pathology and Oral Microbiology, Vinayaka Missions Sankarachariyar Dental, VMRF (DU), Salem, Tamil Nadu, India
2 Professor, Department of Periodontology, Vinayaka Missions Sankarachariyar Dental, VMRF (DU), Salem, Tamil Nadu, India
3 Professor, Department of Oral Pathology, Rajamuthiah Dental College and Hospital, Chidambaram, Tamil Nadu, India
4 Senior Lecturer, Department of Oral Pathology and Oral Microbiology, Vinayaka Missions Sankarachariyar Dental, VMRF (DU), Salem, Tamil Nadu, India
5 Professor and Head, Department of Oral and Maxillofacial Surgery, Butterworth Penang, Malaysia

Correspondence Address:
Dr B. Sekar
Professor and Head of the Department, Department of Oral Pathology and Oral Microbiology, Vinayaka Missions Sankarachariyar Dental, VMRF (DU), Sankakiri Main Road, Salem- 636308, Salem, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jofs.jofs_140_19

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Introduction: For the past decades long-term survival of oral squamous cell carcinoma (OSCC) patients remain unchanged which provides a wide platform for research. Caldesmon (CaD), an actin-myosin binding protein, has a contributing role in cytoskeleton modulation and cell motility. The aim of this study is to evaluate the expression of CaD in metastatic and non-metastatic OSCC and to discuss the possible role of CaD in epithelial mesenchymal transition. Materials and Methods: Archival blocks of 25 metastatic and 25 non-metastatic OSCC patients are included where CaD expression is evaluated immunohistochemically. Results: Overall expression and staining intensity of CaD were statistically significant in different grades of metastatic and non-metastatic OSCC. In summary, high expression of CaD is observed in increasing grades of OSCC but the metastatic potential of the tumour doesn’t seem to have any relation with CaD.


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