Year : 2018  |  Volume : 10  |  Issue : 1  |  Page : 3-6

Importance of depth of invasion in patients with oral squamous cell carcinoma: A review article

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran
2 Oral and Maxillofacial Diseases Research Center, Mashhad, Iran
3 School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Dr. Ala Ghazi
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jofs.jofs_115_17

Rights and Permissions

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Despite several diagnostic and therapeutic advances over the last decades, the rate of mortality and 5-year survival of patients with OSCC has not been improved markedly. The unpredictable behavior of squamous cell carcinoma in digestive and respiratory system has led to search the reliable parameters as prognostic predictors. Histomorphological parameters including the depth of invasion (DOI) may be used as a prognosticate factor in patients with OSCC. It is determined microscopically by detecting the deepest invasive cells in the underlying tissues. Given that planned treatment after histological examination may be changed, measuring the DOI should be considered as a part of routine histological evaluation. In this study, we attempted to review the importance of DOI in the prognosis of cancers as well as its determination in the patients with OSCC lesions.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded626    
    Comments [Add]    

Recommend this journal