REVIEW ARTICLE
Year : 2018  |  Volume : 10  |  Issue : 1  |  Page : 3-6

Importance of depth of invasion in patients with oral squamous cell carcinoma: A review article


1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran
2 Oral and Maxillofacial Diseases Research Center, Mashhad, Iran
3 School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Dr. Ala Ghazi
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jofs.jofs_115_17

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Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Despite several diagnostic and therapeutic advances over the last decades, the rate of mortality and 5-year survival of patients with OSCC has not been improved markedly. The unpredictable behavior of squamous cell carcinoma in digestive and respiratory system has led to search the reliable parameters as prognostic predictors. Histomorphological parameters including the depth of invasion (DOI) may be used as a prognosticate factor in patients with OSCC. It is determined microscopically by detecting the deepest invasive cells in the underlying tissues. Given that planned treatment after histological examination may be changed, measuring the DOI should be considered as a part of routine histological evaluation. In this study, we attempted to review the importance of DOI in the prognosis of cancers as well as its determination in the patients with OSCC lesions.


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