REVIEW ARTICLE
Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 71-74

The expression of Bcl-2 in oral squamous cell carcinoma—A review


Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Chennai, India

Correspondence Address:
Dr. Jayakumar Arumugam
Jeyam Dental Clinic, 45 B6, Salem Main Road, Gandhinagar, Edappadi-637105
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jofs.jofs_88_16

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Currently, oral cancer is one of the most alarming health problems facing mankind. More than 90% of all oral cancers are oral squamous cell carcinoma (OSCC). BCL-2 proteins are one of the most prominent anti-apoptotic proteins expressed in OSCC. They contribute to cancer development and mediate resistance to current anticancer treatments. Various studies have been conducted to evaluate the expression of Bcl-2 in OSCC. This article emphasizes the importance of Bcl-2 expression as a prognostic indicator in OSCC.


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